Leading researchers supply an authoritative survey and analysis of the latest findings on the rapid growth of antisense oligonucleotides therapeutic and their software in numerous in vivo mannequin systems. The e book's high-profile contributors present well timed accounts of their state-of-the-artwork methods, discussing such matters because the synthesis and purification of oligonucleotides, their selection for a particular gene target, totally different strategies of administration, and using numerous cell strains and cell culture systems. Additionally they examine questions of cellular uptake, in vitro organic activity, in vivo biological exercise, the pharmacology and pharmacokinetics of oligonucleotides, and the application of oligonucleotides to the central nervous system.
Review
...a well timed addition to the literature on this field... strongly really helpful each to scientists already engaged in antisense analysis and to newcomers alike...a 'must' for all those wishing to 'stop making sense' with nucleic acid therapeutics in in vivo studies. -Tendencies in Biotechnology
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